The velocity coupling relationship between the moving platform and the frame deflection was analyzed, optical axis stabilization method was deduced, and aiming at the non-linearity, multi-interference in optical axis stabilization, active disturbance rejection controller based on fuzzy reasoning was proposed to control three axis stabilization systems. Through software simulation and experiment: under1Hz disturbance, with respect to parameter identification method, anti-disturbance isolation degree based on active disturbance rejection controller is increased by 7.4 dB, in the experimental condition of the sweep frequency from 1~2 Hz to 2~4 Hz, the anti-disturbance isolation degree of the fuzzy auto disturbance rejection control method decrease only 2.2 dB. Fuzzy auto disturbance rejection controller has better fast response ,smaller super adjustment and frequency adaptability, also can overcome the platform angular motion and uncertainty disturbance.