Digital Elevation Model(DEM) is the digital expression of terrain surface morphology. As an important basic geographic information data, DEM has an important application in the field of natural and human sciences. Therefore, the construction of DEM data with high form accuracy and elevation accuracy has become a hot issue in related research fields. With the development of human society, the transformation and influence of human activities on the topography are becoming more and more significant, the surface modification taken by human activities makes it diversified and discontinuous. At this time, traditional DEM construction methods cannot meet the accuracy requirements of DEM in these areas. To solve this problem, this paper proposes a multi-model collaborative approach to construct DEM. Firstly, the features of the earth’s surface are classified according to their morphological features and semantic information. Then, this research construct DEM according to the design of different features of the earth's surface and the selection of appropriate methods. Finally, the research fuse and stitch the results of DEM to form a regional and complete DEM result. This paper chooses a suburban area of Nanjing as the experimental area and takes a large-scale topographic map as the basic data source to carry out DEM construction experiment. The results show that compared with the traditional DEM construction method, the multi-model collaborative DEM construction method proposed in this paper can effectively guarantee the expression of various types of terrain elements in the experimental area. Especially for the terrain transformed by human activities, such as roads, slopes and other areas, the DEM constructed by this method has a significant advantage in morphological accuracy.At the same time, the height accuracy analysis results based on the verification point method show thatthe elevation accuracy of DEM constructed by this method is also better than that of traditional DEM constructed method. Especially for some areas with regular shape and relatively scarce elevation information, the accuracy advantage of this method is particularly remarkable. This research results prove that the proposed multi-model collaborative DEM construction method is suitable for DEM construction in areas where human activities are transformed or significantly affected.The research of this paper has certain theoretical significance and application value for enriching the method system of DEM construction and analysis, as well as the production of high-precision DEM data in urban areas.