Nd:MgO:LiNbO3 waveguides have been fabricated by proton-exchange method. Employing the prism-coupling, we measured the effective refractive indices of the waveguides to obtain effective index profiles and diffusion coefficient. Infrared absorption spectra of the waveguides have been measured. The results indicate that the properties of the waveguides are similar to those of the proton-exchange MgO:LiNbO3 waveguides.