Cross-phase modulational instability created by two beams of lights in the region of minimum group-velocity dispersion is investigated based on extended nonlinear Schrdinger equation with the fiber loss and high-order dispersion considered. The dispersion equation which describes the cross-phase modulational instability is obtained,and the numerical simulation is done. It is shown that because of the fourth-order dispersion,cross-phase modulational instability occurs at two spectrum regions in both anomalous and normal dispersion regimes of fiber. When second-order dispersion approaches the minimum value at the so-called zero dispersion wavelength,fourth-order dispersion dominates the cross-phase modulational instability and makes a new crest in the gain spectrum. Research also shows that fiber loss reduces the frequency range of the gain spectrum. For a given dispreading distance,the widths of the two spectrum regions increase until overlay when second-order dispersion approaches zero. When two beams of lights have difference,the cross-phase modulational instability is analyzed numerically.