Study of laser microbeam irradiation of biological model tissue and the living cells of plants as well as animals such as soybean cell line, protoplast of mesophyll cells in tobacco, Chinese Hamster Ovary Cell Line (CHO), the 2-cell stage embryos of mouse and rabbit, have been carried out by using XJX-2 ruby laser microbeam system. On the basis of using either naturel chromophore or vital staining, the effective and selective destructions in living cells of plants and animals tested were produced successfully.