• Acta Physica Sinica
  • Vol. 68, Issue 21, 214304-1 (2019)
Bo-Rui Zhou1、2, Yi-Dong Tan2、*, Xue-Ju Shen1、*, Kai-Yi Zhu2, and Li-Ping Bao3
Author Affiliations
  • 1Department of Electronic and Optical Engineering, Army Engineering University of PLA, Shijiazhuang 050051, China
  • 2State Key Laboratory of Precision Measurement Technology and Instrument, Tsinghua University, Beijing 100084, China
  • 3Department of Ultrasound, Peking University Cancer Hospital, Beijing 100042, China
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    DOI: 10.7498/aps.68.20190770 Cite this Article
    Bo-Rui Zhou, Yi-Dong Tan, Xue-Ju Shen, Kai-Yi Zhu, Li-Ping Bao. Mechanism of contrast-enhancement in ultrasound-modulated laser feedback imaging with ultrasonicmicrobubble contrast agent[J]. Acta Physica Sinica, 2019, 68(21): 214304-1 Copy Citation Text show less
    Schematic of ULFI technology.ULFI技术原理图
    Fig. 1. Schematic of ULFI technology.ULFI技术原理图
    Schematic diagram of interaction among microbubbles, light field and sound field.微泡、光场、声场相互作用示意图
    Fig. 2. Schematic diagram of interaction among microbubbles, light field and sound field.微泡、光场、声场相互作用示意图
    Ultrasonic dynamics of microbubble: (a) Curve of microbubble radius; (b) spectrogram of microbubble radius.微泡的超声动态特性 (a)微泡半径变化曲线; (b)微泡半径变化频谱图
    Fig. 3. Ultrasonic dynamics of microbubble: (a) Curve of microbubble radius; (b) spectrogram of microbubble radius.微泡的超声动态特性 (a)微泡半径变化曲线; (b)微泡半径变化频谱图
    Curves of microbubble scattering acoustic pressure.微泡散射声压曲线
    Fig. 4. Curves of microbubble scattering acoustic pressure.微泡散射声压曲线
    Curves of microbubbles scattering coefficient.微泡群散射系数变化曲线
    Fig. 5. Curves of microbubbles scattering coefficient.微泡群散射系数变化曲线
    Flow chart of optical scattering parameters selection in Monte Carlo simulation.蒙特卡罗仿真光散射参数的选择流程图
    Fig. 6. Flow chart of optical scattering parameters selection in Monte Carlo simulation.蒙特卡罗仿真光散射参数的选择流程图
    Monte Carlo simulation of backscattered spot patterns: (a) 0.9% NaCl; (b) 0.9% NaCl with microbubbles; (c) 1% intralipid; (d) 1% intralipid with microbubbles.蒙特卡罗仿真背向散射光斑图 (a) 0.9% NaCl; (b) 0.9% NaCl添加微泡; (c) 1%的脂肪乳剂; (d) 1%的脂肪乳剂添加微泡
    Fig. 7. Monte Carlo simulation of backscattered spot patterns: (a) 0.9% NaCl; (b) 0.9% NaCl with microbubbles; (c) 1% intralipid; (d) 1% intralipid with microbubbles.蒙特卡罗仿真背向散射光斑图 (a) 0.9% NaCl; (b) 0.9% NaCl添加微泡; (c) 1%的脂肪乳剂; (d) 1%的脂肪乳剂添加微泡
    Experiment system.实验系统
    Fig. 8. Experiment system.实验系统
    Acoustic pressure-ULFI signal curve of the microbubble solution and 0.9% NaCl solution: (a) Total curve; (b) fundamental signal; (c) second harmonic signal; (d) third harmonic signal.微泡溶液和0.9%NaCl溶液中的声压-ULFI信号曲线 (a)总曲线; (b)基波信号; (c)二次谐波信号; (d)三次谐波信号
    Fig. 9. Acoustic pressure-ULFI signal curve of the microbubble solution and 0.9% NaCl solution: (a) Total curve; (b) fundamental signal; (c) second harmonic signal; (d) third harmonic signal.微泡溶液和0.9%NaCl溶液中的声压-ULFI信号曲线 (a)总曲线; (b)基波信号; (c)二次谐波信号; (d)三次谐波信号
    Acoustic pressure-ULFI signal curves of 1% intralipid solution and microbubble intralipid mixed solution.1%的脂肪乳剂溶液和微泡、脂肪乳剂混合溶液中的声压-ULFI信号曲线
    Fig. 10. Acoustic pressure-ULFI signal curves of 1% intralipid solution and microbubble intralipid mixed solution.1%的脂肪乳剂溶液和微泡、脂肪乳剂混合溶液中的声压-ULFI信号曲线
    ${\rho _{\rm{L}}}/{\rm{kg}} \cdot {{\rm{m}}^{ - 3}}$${P_0}/{\rm{kPa}}$$\sigma /{\rm{N}} \cdot {{\rm{m}}^{ - 1}}$$\chi /{\rm{N}} \cdot {{\rm{m}}^{ - 1}}$$c/{\rm{m}} \cdot {{\rm{s}}^{ - 1}}$$\varepsilon /{\rm{nm}}$${\mu _{{\rm{sh}}}}/{\rm{Pa}} \cdot {\rm{s}}$$\gamma $
    99810100.0510.26150050.0031.07
    Table 1.

    Rayleigh-Plesset equation simulation parameters.

    Rayleigh-Plesset方程仿真参数

    溶液种类背向散射光子数$\dfrac{{{\simfont\text{调制}} + {\simfont\text{附加调制}}}}{{\simfont\text{未调制}}}$
    调制未调制附加调制
    0.9%的NaCl溶液935445080020.75%
    0.9%的NaCl、微泡混合液937946070460730.36%
    1%的脂肪乳剂溶液8435296601.59%
    1%的脂肪乳剂、微泡混合液975268570.20%
    Table 2.

    Results of Monte Carlo simulation.

    蒙特卡罗仿真结果

    Bo-Rui Zhou, Yi-Dong Tan, Xue-Ju Shen, Kai-Yi Zhu, Li-Ping Bao. Mechanism of contrast-enhancement in ultrasound-modulated laser feedback imaging with ultrasonicmicrobubble contrast agent[J]. Acta Physica Sinica, 2019, 68(21): 214304-1
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