It has been shown by intensive research activities in the optics and optoelectronics fields that many novel properties unimaginable with conventional optical fibers can result from the holey structure in photonic crystal fibers (PCF), including flexible design of dispersion, enhanced nonlinearity, endlessly single mode operation, and high birefringence. Photonic crystal fiber has been successfully applied in femtosecond laser technology and pushed the output performance of femtosecond fiber laser to match with the solid-state laser system. A review of recent work on high power femtosecond photonic crystal fiber laser oscillator, amplifier and their applications are proposed. Feasible scenario in future applications of high pulse energy large mode area photonic crystal fiber lasers will be come soon.