• Advanced Photonics Nexus
  • Vol. 3, Issue 1, 016012 (2024)
Arturo I. Hernandez-Serrano1, Xuefei Ding1, Jacob Young1, Goncalo Costa1..., Anubhav Dogra1, Joseph Hardwicke2,3 and Emma Pickwell-MacPherson1,*|Show fewer author(s)
Author Affiliations
  • 1University of Warwick, Department of Physics, Coventry, United Kingdom
  • 2Warwick Medical School, University of Warwick, Coventry, United Kingdom
  • 3Institute of Applied and Translational Technologies in Surgery, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
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    DOI: 10.1117/1.APN.3.1.016012 Cite this Article Set citation alerts
    Arturo I. Hernandez-Serrano, Xuefei Ding, Jacob Young, Goncalo Costa, Anubhav Dogra, Joseph Hardwicke, Emma Pickwell-MacPherson, "Terahertz probe for real time in vivo skin hydration evaluation," Adv. Photon. Nexus 3, 016012 (2024) Copy Citation Text show less

    Abstract

    This study introduces a handheld terahertz (THz) scanner designed to quantitatively evaluate human skin hydration levels and thickness. This device, through the incorporation of force sensors, demonstrates enhanced repeatability and accuracy over traditional fixed THz systems. The scanner was evaluated in the largest THz skin study to date, assessing 314 volunteers, successfully differentiating between individuals with dry skin and hydrated skin using a numerical stratified skin model. The scanner measures and displays skin hydration dynamics within a quarter of a second, indicating its potential for real-time, noninvasive examinations, opening up opportunities for in vivo and ex vivo diagnosis during patient consultations. Furthermore, the portability and ease of use of our scanner enable its widespread application for in vivo and ex vivo diagnosis during patient consultations, potentially allowing in situ biopsy evaluation and elimination of histopathology processing wait times, thereby improving patient outcomes by facilitating simultaneous tumor diagnosis and removal.
    Impulse(t)=FFT1{FFT[Esamp(t)]FFT[Eref(t)]},

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    minXexp(t)Xtheo(H0,H1,d,t)22,

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    i=1Jηiϵiϵeffϵi+2ϵeff,

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    Zm=ζmZm+1+iζmtan(kmtm)ζm+iZm+1tan(kmtm),

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    Γ0=Z1ζ0Z1+ζ0.

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    Esim(t)=FFT1(Γ0E0),

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    Arturo I. Hernandez-Serrano, Xuefei Ding, Jacob Young, Goncalo Costa, Anubhav Dogra, Joseph Hardwicke, Emma Pickwell-MacPherson, "Terahertz probe for real time in vivo skin hydration evaluation," Adv. Photon. Nexus 3, 016012 (2024)
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