BIBO (BiB3O6) crystal is a novel nonlinear crystal, which has stable physical and chemical properties, high destroy threshold, and big nonlinear effective coefficient, so BIBO crystal can be used as frequency conversion device to obtain efficient second harmonic wave generation. In this paper, high efficient blue laser at 473 nm was generated by BIBO crystal inserted in a diode-pumped Nd:YAG (Y3Al5O12) laser at 946 nm for intra-cavity frequency doubling. A home made laser diode was used to end pump a piece of 2.2 mm long Nd:YAG crystal dopped with 1.0 at.-%. With 1.6 W pumped laser, 183 mW TEM00 mode stable blue laser output was obtained by a 5 mm long Ⅰ typed BIBO crystal, conversion efficiency up to 11.4%, which was about 45% higher than a 10 mm long Ⅰ typed LBO (LiB2O3) crystal.