In order to resolve the difficult to hardware implementation of the whole vector quantization-based, predictive coding-based and transform coding-based compression scheme caused by the large volume of data, small spectral redundancy and line frequency variability etc. in multi-spectral space camera, an image compression scheme based on ADV212 was proposed in space camera. Firstly, custom-specific mode was presented based on the working principle of adv212 and CCD image properties. In the Custom-specific mode, an ADV212 is able to compress 8 channel CCD data by proposed image frame and interrupt processing strategy using pipelining. Then, this paper analyses the two parameters which affect the quality of image compression. A (10, 5) setting the quantization step method was proposed. This method makes the rate control error reduces 16.385%. Finally, the verification experiments to ADV212 compression system using ground test equipment were carried out. The experiments results showed that compression system can be fast and stable work. All PSNR were more than 30dB in the compression ratio of 2∶1 to 32∶1. Compared with traditional approaches, the proposed method could improve the average PSNR by 2.49 dB in the lossy compression mode when the compression ratio is 1bpp. They effectively solve the difficult of hardware implementation of the whole wavelet-based compression scheme.