The modeling and optimizing of fuse and warhead coordination of combination laser proximity fuze, which detects a warship target with ship-borne radar, were discussed. By means of building the 3D model of warship and the detecting model of laser proximity fuse, a better solution was provided to the problem of the damage effectiveness analysis, which was due to the complex surface of warships and the strong coupling between laser beam and vehicle body. Then, the Monte Carlo simulation, which has been widely used in the guidance accuracy evaluation, was used to calculate damage probability with different fuse-warhead coordination models. The modeling and simulation method provides an effective and universal way to optimize the coordination of any kind of fuse and warhead.