The adaptive optical system of a large ground-based telescope needs to use a high-speed and high-sensitivity camera to measure the wavefront error in real time to obtain a target image close to the diffraction limit. The multi-tap electron-multiplying charge coupled device (EMCCD) camera is one of the best choices for adaptive optical wavefront detection. Based on the 8-tap CCD220, a high-speed (2000f/s), high-precision and multi-channel synchronous timing generator is designed. A variety of pixel combinations have been implemented on the device, thus the camera frame rate is increased to 3500f/s (2×2 merge) and 5700f/s (4×4 merge), and the area of interest of the camera can be controlled. The stepping accuracy of the timing generator can reach 2.5ns, and the phase jitter of each driving signal output can reach below 200ps.