• Acta Physica Sinica
  • Vol. 69, Issue 16, 163301-1 (2020)
Jia-Feng Yao, Jian-Fen Wan, Lu Yang, Kai Liu*, Bai Chen, and Hong-Tao Wu
Author Affiliations
  • College of Electrical and Mechanical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
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    DOI: 10.7498/aps.69.20200601 Cite this Article
    Jia-Feng Yao, Jian-Fen Wan, Lu Yang, Kai Liu, Bai Chen, Hong-Tao Wu. Electrical characteristics of cells with electrical impedance spectroscopy[J]. Acta Physica Sinica, 2020, 69(16): 163301-1 Copy Citation Text show less
    Simulation model (a)−(c) Model of cell; (d), (e) model of simulation area.
    Fig. 1. Simulation model (a)−(c) Model of cell; (d), (e) model of simulation area.
    Simulation results of different cells and Cole-Cole Plot: (a) Simulation results of different frequencies of different cells; (b) Cole-Cole Plot of different cells.
    Fig. 2. Simulation results of different cells and Cole-Cole Plot: (a) Simulation results of different frequencies of different cells; (b) Cole-Cole Plot of different cells.
    Simulation results of no-nuclear cells with or without membrane: (a) Simulation results of non-nucleated cells with different frequencies; (b) the Cole-Cole Plot corresponding to the simulation results.
    Fig. 3. Simulation results of no-nuclear cells with or without membrane: (a) Simulation results of non-nucleated cells with different frequencies; (b) the Cole-Cole Plot corresponding to the simulation results.
    Simulation results of cells with different nuclear radius: (a) Simulation results of cells at different frequencies; (b), (c) Cole-Cole Plot of different nuclear radius.
    Fig. 4. Simulation results of cells with different nuclear radius: (a) Simulation results of cells at different frequencies; (b), (c) Cole-Cole Plot of different nuclear radius.
    Experimental set-up.
    Fig. 5. Experimental set-up.
    Experiment: (a) Object and model of dead and alive yeast; (b) Cole-Cole Plot of 20% dead and alive yeast.
    Fig. 6. Experiment: (a) Object and model of dead and alive yeast; (b) Cole-Cole Plot of 20% dead and alive yeast.
    参数正常细胞癌细胞
    导电率σ/S·m–1环境0.60.6
    细胞膜5.6 × 10–59.1 × 10–6
    细胞质1.310.48
    核膜1.11 × 10–24.4 × 10–3
    核质2.041.07
    相对介电常数环境8080
    细胞膜12.89.8
    细胞质6060
    核膜10660.3
    核质120120
    几何参数/μm仿真区域(L × L) 20 × 2020 × 20
    电极 $ (l) $2 × 42 × 4
    细胞半径(R1) 3.35.2
    细胞核半径(R2) 2.84.4
    细胞膜厚(d1) 0.0070.007
    核膜厚(d2) 0.040.04
    Table 1.

    Simulation parameters of normal and malignant (farage) onsillar B-cells[19].

    正常B细胞及病变B细胞的仿真参数

    Jia-Feng Yao, Jian-Fen Wan, Lu Yang, Kai Liu, Bai Chen, Hong-Tao Wu. Electrical characteristics of cells with electrical impedance spectroscopy[J]. Acta Physica Sinica, 2020, 69(16): 163301-1
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