As to the strategy of penetration against the MissileDefenceSystem for Hypersonic Glide Vehicle (HGV)an approach of lateral weaving maneuver based on threat timewindow was proposed.A damage probability model was established based on the combination of radarmissile and HGV.The exposed Radar Cross Section (RCS) of HGV was controlled by lateral weaving maneuver.The optimal penetration trajectory was designed based on the minimax theorywhich minimized the maximal damage probability of HGV for all the threat timewindows.Simulation was madeand the result demonstrated that this approach can reduce HGVs probability of being damagedand improve its survivability during penetration effectively at the cost of more voyage and time.