To countermeasure semi-active laser guided missiles, high-repetition-rate laser interference is an effective means.In order to analyze the interference efficiency of high-repetition-rate laser to missiles adopting different pulse admission techniques, a model describing high-repetition-rate laser interference efficiency is established.The success probability of the first interference of the seekers wave gates, the success probability of the second interference, and the interference times required to deflect the target indication signals out of the wave gates are simulated, and the effects of high-repetition-rate laser frequency, wave gates width and other factors on the interference efficiency are studied.The simulation results show that as for missiles that adopt the first (last) pulse admission technique, the higher the interference frequency and the wider the wave gates width, the higher the success probability of interference, the fewer times required to deflect the target indication signals out of the wave gates.When the missile adopts the optimal timing pulse admission technique, in the first interference, the higher the interference frequency and the wider the wave gates width, the higher the success probability of interference.Under the condition of successful first interference, the success probability of the second interference tends to level off with the increase of the frequency of interference laser.The optimal jamming frequency required to deflect the target indication signals out of the wave gates is located near the reciprocal of the wave gates width.The research results of this paper can provide reference for equipment development and operational application.