Rural-urban integration is an inevitable trend of the development of rural-urban relations. Studies on urban-rural integration are the requirement for giving play to the comprehensive advantages of geography in order to serve the national strategy. This paper took Huaihai Economic Zone as the research object, constructed multi-dimensional index system, and measured the level of urban-rural integration. The characteristics of spatio-temporal evolution and its driving mechanism were also discussed. Some conclusions were drawn as follows. The difference of urban-rural integration level among cities in Huaihai Economic Zone was relatively small. The level of urban and rural integration showed the characteristics of agglomeration in space. For most cities, local spatial structure of urban-rural integration was more dynamic, and its fluctuation was relatively small. Spatial pattern evolution showed the characteristics of strong integration. Factors of the city itself had more influence on the change of spatial structure of urban-rural integration. It was less affected by the spillover effect of the level of urban-rural integration in neighboring cities. The change of urban-rural integration in the cities was driven by economic development and urbanization. The change of urban-rural integration in the cities, which was at low level, was restrained by urban employment and government action. The change of urban-rural integration in the cities, which was at high level, was restrained by industry and government action. Finally, different countermeasures and suggestions were put forward for different types of cities.