A design to realize electro-optic Q-switch in Nd∶YVO4 laser without polarizer is presented, in which a Nd∶YVO4 crystal with a wedge angle is used by analyzing the polarization of natural birefringent crystal. This design has the advantages of simplifying cavity components, shortening cavity length, and reducing cavity loss, and can obtain higher power and narrower pulse width. Voltage-decreased Q-switching is realized by using a La3Ga5SiO14 crystal and a Nd∶YVO4 crystal with the size of 3 mm×3 mm×5 mm, 10° wedge angle. 2.2 W average power, 6.3 ns pulse width, optical-to-optical efficiency of 39.2%, and more than 300 kW peak power are obtained when the repetition rate is 1 kHz.