Health is a key factor that affects the development of different countries and regions. It is very important to understand the health status of the residents in the Belt and Road countries to further explore the health cooperation along the Belt and Road. This paper selected four representative health indicators, including life expectancy at birth, premature noncommunicable disease mortality, total fertility, and tuberculosis incidence, and used Moran's I index and Getis-Ord G index to conduct spatial statistics on the health status of 135 countries along the Belt and Road. This paper analyzed the spatial auto correlation of health status and the temporal and spatial patterns of health status. We found that the health indicators of most countries along the Belt and Road showed a trend toward improvement and optimization between 2000 and 2016. Health indicators of Belt and Road countries showed significant positive spatial auto correlation. In general, countries in Europe hadexcellent health condition, countries in South America, North America, and Oceania werein a good health condition, and countries in Asia werein good health condition as well, but the countries in Southeast Asia had high incidence of tuberculosis. The health status of the countries in Africa had improved significantly, but still in a poorhealth condition. Member countries should further strengthen the cooperation in health to promote the development of the Healthy Silk Road.