A low-loss UV hollow-core anti-resonant optical fiber is designed by simulation. Firstly, a theoretical model of the UV hollow-core anti-resonant optical fiber is established based on the finite element method. Secondly, the performance and loss values of the optical fiber are further optimized by adjusting the parameters of the reflective layer and air filling ratio, and controlling the light propagation and reflection using the anti-resonance effect. Finally, the finite element method is used to simulate the designed UV hollow-core anti-resonant optical fiber,which results in a minimum transmission loss of 0.003 26 dB/m at a transmission wavelength of 375 nm, corresponding to a bending loss of 0.006 25 dB/m at a bending radius of 5 cm, and a high efficiency and stable mode output.An important reference and guidance are provided for the development of high-performance simulation design of UV hollow-core anti-esonant fibers, which offers further possibilities for practical applications.