Contents
2014
Volume: 7 Issue 2
16 Article(s)

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Research Article
Britton Chance's lab and thereafter: From NIR spectroscopy to molecular sensing via nanotechnology
Kyung A. Kang
I was fortunate to work with/for Dr Britton Chance as his postdoctoral fellow, in the Biochemistry and Biophysics Department at the University of Pennsylvania, between August 1991 and January 1994. As anyone who worked for him, I had a sufficient dosage of \Britton Chance" over the years. Initially, to me, I felt
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 7, Issue 2, 1330004 (2014)
Imaging tumor hypoxia: Blood-borne delivery of imaging agents is fundamentally different in hypoxia subtypes
Peter Vaupel, and Arnulf Mayer
Dedicated to the memory of Professor Britton Chance on the occasion of his 100th birthday (July 24th, 2013), and remembering many exciting discussions on the oxygenation of breast cancer, on tumor hypoxia in general and imaging of the oxygenation status of malignant tumors. Hypoxic tissue subvolumes are a hallmark feat
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 7, Issue 2, 1330005 (2014)
A review of synthetic methods for the production of upconverting lanthanide nanoparticles
Christian F. Gainer, and Marek Romanowski
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 7, Issue 2, 1330007 (2014)
Real-time in situ detection and quantification of bacteria in the Arctic environment
Linda Powers, Walther R. Ellis Jr., and Christopher R. Lloyd
At present, there are no methods that determine the total microbial load on an abiotic substrate in real time. The utility of such a capability ranges from sterilization and medical diagnostics to the search for new microorganisms in the environment and study of their ecological niches. We report the development of a h
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 7, Issue 2, 1350038 (2014)
3D imaging of the mitochondrial redox state of rat hearts under normal and fasting conditions
He N. Xu, Rong Zhou, Lily Moon, Min Feng, and Lin Z. Li
The heart requires continuous ATP availability that is generated in the mitochondria. Although studies using the cell culture and perfused organ models have been carried out to investigate the biochemistry in the mitochondria in response to a change in substrate supply, mitochondrial bioenergetics of heart under normal
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 7, Issue 2, 1350045 (2014)
Adaptive hp finite element method for fluorescence molecular tomography with simplified spherical harmonics approximation
Hongbo Guo, Yuqing Hou, Xiaowei He, Jingjing Yu, Jingxing Cheng, and Xin Pu
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 7, Issue 2, 1350057 (2014)
From identification of fluorescent flavoproteins to mitochondrial redox indicators in intact tissues
Ilmo E. Hassinen
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 7, Issue 2, 1350058 (2014)
Optical coherence tomography of the living human kidney
Peter M. Andrews, Hsing-Wen Wang, Jeremiah Wierwille, Wei Gong, Jennifer Verbesey, Matthew Cooper, and Yu Chen
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 7, Issue 2, 1350064 (2014)
Targeted principle component analysis: A new motion artifact correction approach for near-infrared spectroscopy
Meryem A. Yücel, Juliette Selb, Robert J. Cooper, and David A. Boas
As near-infrared spectroscopy (NIRS) broadens its application area to different age and disease groups, motion artifacts in the NIRS signal due to subject movement is becoming an important challenge. Motion artifacts generally produce signal fluctuations that are larger than physiological NIRS signals, thus it is cruci
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 7, Issue 2, 1350066 (2014)
Quantitative redox imaging biomarkers for studying tissue metabolic state and its heterogeneity¤
He N. Xu, and Lin Z. Li
NAD+/NADH redox state has been implicated in many diseases such as cancer and diabetes as well as in the regulation of embryonic development and aging. To fluorimetrically assess the mitochondrial redox state, Dr. Chance and co-workers measured the fluorescence of NADH and oxidized flavoproteins (Fp) including flavin–a
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 7, Issue 2, 1430002 (2014)
Citation analysis of the scientific publications of Britton Chance in ISI citation indexes
Lin Z. Li, Loet Leydesdorff, Shoko Nioka, Nannan Sun, and Eugene Garfield
Britton Chance was a pioneer in many scientific fields such as enzymatic reaction kinetics, bioenergetics, metabolism, in vivo NMR, and biophotonics. As an engineer, physical chemist, physicist, physiologist, biophysicist, biochemist, innovator and educator, he had worked in diversified fields over extended periods bet
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 7, Issue 2, 1430003 (2014)
Near-infrared spectroscopy (NIRS) as a useful tool to evaluate the treatment efficacy of positive airways pressure therapy in patients with obstructive sleep apnea syndrome (OSAS): A pilot study
Zhongxing Zhang, Maja Schneider, Ursula Fritschi, Isabella Lehner, and Ramin Khatami
In obstructive sleep apnea syndrome (OSA) the periodic reduction or cessation of breathing due to narrowing or occlusion of the upper airway during sleep leads to an impaired cerebral vascular autoregulation that is associated with an increased cardiovascular risk, including stroke. Continuous positive airways pressure
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 7, Issue 2, 1450014 (2014)