Many remote sensing image classifiers are limited in their ability to combine spectral features with spatial features. Multi-kernel classifiers, however, are capable of integrating spectral features with spatial or structural features using multiple kernels and summing them for final outputs. Using a support vector machine (SVM) as classifier, different multi-kernel classifiers are constructed and tested using 64-band Operational Modular Imaging Spectrometer II hyperspectral image of Changping Area, Beijing City. Results show that by integrating spectral and wavelet texture information, multi-kernel SVM classifiers can obtain more accurate classification results than sole-kernel SVM classifiers and cross-information SVM kernel classifiers. Moreover, when the multi-kernel SVM classifier is used, the combination of the first four principal components from principal component analysis and wavelet texture provides the highest accuracy (97.06%). Multi-kernel SVM is therefore an effective approach to improve the accuracy of hyperspectral image classification and to expand possibilities for remote sensing image interpretation and application.