In order to solve the problem on the information utilization and noise reduction of angular weighting methods by Mie scattering calculation for multiangle dynamic light scattering, multiple angle-weighting method was proposed, in which the Mie scattering′s spatial character of all granularities at each angle is as the angular weighting factor and that of each granularity is as the nuclear matrix weighting factor. By using this multiple angle-weighting method, the regularization inversions for both simulated and measured multiangle dynamic light scattering data were carried out. Compared with the inversion results of the light intensity ratio method and the light intensity mean method, the inversion results for multiangle dynamic light scattering are closely related to the angular weighting methods. In the absence of noise, the intensity ratio method and the multiple angle-weighting method can obtain accurate particle size distributions, but the information utilization for the light intensity mean method is not sufficient. With the increase of the noise level, the inversion results of the ratio of light intensity are rapidly getting worse, which shows the lower noise reduction capability. Multiple angle-weighting method, taking the information utilization and noise reduction capability into account, can better show the advantage for increase of information and effectively suppresses the noise influence when the scattering angles are increased. The method significantly improves the accuracy of particle measurement in the multiangle dynamic light scattering, especially for the multi-peak distribution particle system.