The cause of crosstalk based on multi-view autostereoscopic display was analyzed. The relation between sweet spots and parallax barrier parameters was deduced. Then, analysis of the model of crosstalk was processed respectively in vertical and horizontal directions to the flat-panel displays, which aimed to obtain the distribution characteristics of crosstalk in three-dimensional space before the screen. The simulation results show that viewing zone in vertical direction along the screen is greater than it in horizontal direction. And, each view has multiple observation points without any crosstalk in a horizontal direction parallel to the screen, but in the direction perpendicular to the screen, each view has only one such point. Through the simulation analysis of viewing zone, the accuracy of the crosstalk calculation was further validated. The research results of this paper establish a simulation basic platform for the optimum design and concrete realization of autostereoscopic display system.