A novel miniaturized camera module with 1.3 megapixels for electronic endoscope is developed and presented. This module realizes longdistance and highfidelity transmission of image data adopting LowVoltage Differential Signaling technology. It includes a 1/5.5 inch CMOS image sensor with a resolution of 1 280×1 024 pixel2, a small integrated lens with field of view of 140° and two electric circuit boards. The lens fixed with inner screw thread is cemented directly onto the nonoptical part of the image sensor′s surface. Two printed circuit boards are assembled vertically, which reduces the size of the module down to 5.5 mm in width, 5.2 mm in height and 15.0 mm in length. The 10bit parallel digital signals are encoded into lowvoltage differential signals before they are output through a twisted pair. A demonstration system is developed to evaluate the performance of the camera module. Experimental results show that the module′s resolution reaches to 136 lp·mm－1, and the image transmission length is over 2 meters. The compact size, high resolution image, wide field of view and longdistance transmission enable the camera module to be used in video endoscopy, especially for HDTV gastroscopes and colonoscopes.