3D printing is an emerging product manufacturing technology characterized by additive manufacturing, which has a profound impact on multiple industries and fields in society. In recent years, many universities have gradually begun to research and explore the application of this technology in the curriculum teaching. In response to the common problems such as the single teaching content, limited teaching time, and outdated teaching methods, a 3D printing practical teaching platform was constructed in the Fundamental Industry Training Center of Tsinghua University. This paper discusses the construction experience and innovation in the diverse model design, combination of the traditional and emerging technologies, the online digital resource development, and the research project integration. The platform has played an important role in the teaching practice of many courses and students’ scientific and technological innovation activities, and students’ engineering thinking, innovation ability, design ability and independent learning ability have been well exercised and improved.