The present paper proposes a novel design for achieving single-polarization single-mode (SPSM) operation at 1550 nm in photonic crystal fiber (PCF), using a rectangular-lattice PCF with two lines of three central air holes enlarged. The proposed PCF composed entirely of silica material is modeled by a full-vector finite element method with anisotropic perfectly matched layers. Simulations show that single-polarization operation within broad wavelength range can be easily realized with the proposed structure. The wide-band SPSM operation features, the low confinement losses, and the small effective mode area are the main advantages of the proposed PCF structure. A SPSM-PCF with confinement loss less than 0.1 dB/km within wavelength range from 1370 to 1610 nm and effective mode area about 4.7 micron2 at 1550 nm is numerically demonstrated.