• Chinese Physics B
  • Vol. 29, Issue 10, (2020)
Huiwen Wang and Yunjie Zhao
Author Affiliations
  • Institute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, China
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    DOI: 10.1088/1674-1056/abb7f3 Cite this Article
    Huiwen Wang, Yunjie Zhao. Methods and applications of RNA contact prediction[J]. Chinese Physics B, 2020, 29(10): Copy Citation Text show less

    Abstract

    The RNA tertiary structure is essential to understanding the function and biological processes. Unfortunately, it is still challenging to determine the large RNA structure from direct experimentation or computational modeling. One promising approach is first to predict the tertiary contacts and then use the contacts as constraints to model the structure. The RNA structure modeling depends on the contact prediction accuracy. Although many contact prediction methods have been developed in the protein field, there are only several contact prediction methods in the RNA field at present. Here, we first review the theoretical basis and test the performances of recent RNA contact prediction methods for tertiary structure and complex modeling problems. Then, we summarize the advantages and limitations of these RNA contact prediction methods. We suggest some future directions for this rapidly expanding field in the last.
    Huiwen Wang, Yunjie Zhao. Methods and applications of RNA contact prediction[J]. Chinese Physics B, 2020, 29(10):
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