Vibration has direct impact on the reliability and stability of the optoelectronic equipment in the airborne environment. Reasonable anti-vibration design can effectively isolate the vibration passed from the aircraft to the optoelectronic equipment, and guarantee the stability and tracking accuracy of the equipment. We made a deep analysis to the anti-vibration failure exposed at the beginning of the design of an airborne optoelectronic equipment, and found that it was caused by the increasing of system twist vibration due to the eccentricity of the anti-vibration system. Then, improvement was made to design of the anti-vibration by synthesizing the feasibility and operability of different methods such as gravity center adjustment, damper position adjustment, damper stiffness matching and structural optimization. The results of simulation and test show that the improved scheme can effectively isolate the vibration of the aircraft, and obtain good anti-vibration effect.