A camera system is designed based on the large area array CMOS APS image sensor LUPA-4000.Through analyzing the timing of LUPA-4000,the incorporate program comprised CMOS image sensor driving,communication and data format conversion is described with VHDL.Each program module is specified.FPGA (field programmable gate array) is chosen as the driving signals′ hardware carrier.The circuit system is designed.Driving signals of CMOS image sensor is tested after program loading.Pixel integration control signals′ waveforms are given.The whole system runs steadily and reliably.Its communication with computer is exact and its data transfer with lower computer is accurate.Image with high quality is taken after installing optical system.