Aimed at the aerial threats in systematic combat of multi-platform, multi-target under complicated environment, the design philosophy of multi-missile cooperative operation is proposed with its key technologies.First, analysis is made to the application and development of the multi-missile cooperative guidance in the world.Then the combat system and operation tactics of multi-missile cooperative combat for air defense are discussed.Based on which, the design concepts of the key technologies of multi-missile cooperation for air defense are proposed, including such technologies of overall technology of multi-missile cooperation, flight control of multi-missile formation, data chaining, and confirmatory experimentation.Some ideas about the development of multi-missile cooperative guidance are given in the end.