To explore the correlation between the concentrations of PM2.5, NO2 in atmosphere and tourism activities as well as weather factors in Zhangjiajie, China, an ecotourism city, the method of multifractal detrended cross-correlation analysis (MFDCCA) was used. Firstly, the cross-correlation test was carried out and the results indicate that cross-correlation behaviors exist statistically between them.Then the multifractal characteristics between PM2.5, NO2 and number of tourists, average temperature and relative humidity in both low and high tourism seasons were compared. It is found that in the off-season of tourism, PM2.5 and NO2 concentration of Zhangjiajie is affected by relative humidity in a wide range of fluctuations, and is more likely to have lower concentrations. While in the peak tourism season, PM2.5 and NO2 concentration of Zhangjiajie fluctuates widely under the influence of tourism activities, and tends to appearhigh concentration values.