Taking optimization of an ISAR serial simulation program as an example, the optimization method for radar simulation operating efficiency is studied based on multi-core computer.First, several commonly used parallel algorithms for radar signal simulation are summarized, including both the advantages and disadvantages of each algorithm, and the parallel granularity of radar simulation is also analyzed.Then, the time consumption of each computing unit, such as the computing unit for target echo generation, for simulation result display, and for pulse compression, is studied, as well as their optimizing strategy.The test results are analyzed.Finally, optimization of the ISAR serial simulation example is carried out by using various strategies, including high performance function library, multi-channel parallel pulse compression, fast recursive algorithm for echo simulation, target echo parallel simulation and pipeline parallelization.After comprehensive optimization, the program runs 6.7 times faster than before, showing the effectiveness and applicability of these optimization strategies.