Based on research idea of Quantitative Structure-Property Relationship, parameters of physicochemical properties refractive index and density as well as the structure parameter molar refraction were correlated with the component parameter boron content, the relationship between material structure, composition and property was responsed by a mathematical model to calculate the boron content of boron doped stress application preform. For boron doped stress application preform, molar refraction of B2O3 and SiO2 was calcuated by the experimental results are 10.546 13 and 7.373 32, respectively. The simulation model and caculated results were verified by experimental data. The relative errors of boron content between calculated values and measured values are within 0.5%. The results show that the precision of simulation model is high enough to meet the industrial production demand for estimating the boron content of boron doped stress application preform.