The nonuniformity in the infrared focal plane array limits the quality of infrared imaging system. A new nonuniformity correction procedure based on the unified photoresponse characteristics of infrared focal plane arrays and the correction ratio based on the chi-square histogram were presented. The correction output of each detector took both its observed value and the average response of the focal plane array into account. The correction parameters were obtained by establishing the relationship between the difference of the observed value and its ideal response and the average response of the focal plane array. The proposed correction ratio took into account of both spatial and temporal response characteristics of focal plane arrays, thus it gave more reasonable results on the measurement of the degree of nonuniformity. Experimental results show that its performance is better than that of the two-point correction and the quadratic curve fitting correction using the input values, and has excellent correction capability to the pixels with abnormal responses. In addition, the algorithm has the advantages of high correction precision, less correction factors and easy to real-time processing, which enhances its utility value.