A CMOS Image Sensor Acquisition Multi-Mode System development is designed based on a FPGA array. The development and mode-switching of three kinds of modes such as ordinary mode, speed mode and TDI mode are studied. Based on the principle and characteristics of CMOS array sensor, the design of chip and the external circuit are suitable for the realization of CMOS array acquisition of three modes selection. After analyzing characteristics of CMOS array acquisition under the three modes, the hardware circuit based on FPGA chip are used as the core control of the whole system, and the internal function modules of the FPGA chip are divided with the Verilog language, which including the simulation of the SCCB protocol to complete the register CMOS sensor configuration, open up the cache synchronization FIFO, RAM etc. The USB chip firmware and driver of computer are designed, the image data are processed and displayed with mixed VB and MATLAB.