Edge color dot Mura appeared and became more severe as the light or boot screen lasted longer. In order to improve edge color dot Mura defect of panel and improve the quality of the company's products， the effective improving measurements of edge color dot Mura was summarized， including pixel design， manufacturing process， materials and so on. Finally， through the measurements above， the incidence of edge color dot Mura defect was reduced from 35% to 0， which could effectively improve the yield of products.