Due to the development of liquid crystal display (LCD) technology, large-size and high-resolution thin film transistor-liquid crystal display (TFT-LCD) have emerged, and the dedicated timing controller (T-CON) is unable to meet the applications in special environments. In order to improve the performances of large-size LCD in special environments, a driving circuit for high-resolution and large-size LCD is designed. Field-programmable gate array (FPGA) is used as the core controller, supplemented by the necessary peripheral circuits to drive the large-screen LCD. At the same time, the circuit state monitoring, gamma online adjustment and parameter configurable functions are realized, which greatly improves the reliability and flexibility of the circuit. And the driving circuit is verified by experiments, and the effectiveness of the circuit is verified by experimental results.