• Chinese Journal of Lasers
  • Vol. 51, Issue 9, 0907010 (2024)
Yingshu Cui1、2, Yi Li2、**, and Xiaosong Li1、*
Author Affiliations
  • 1Department of Oncology, the Fifth Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, Beijing 100039, China
  • 2Chinese People’s Liberation Army (PLA) Medical School, Beijing 100853, China
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    DOI: 10.3788/CJL231388 Cite this Article Set citation alerts
    Yingshu Cui, Yi Li, Xiaosong Li. Recent Advancements in Near‐Infrared Light Immunotherapy Targeted on Tumor Microenvironment[J]. Chinese Journal of Lasers, 2024, 51(9): 0907010 Copy Citation Text show less
    Schematic diagram of cell death induced by NIR-PIT [17]
    Fig. 1. Schematic diagram of cell death induced by NIR-PIT [17]
    Biological mechanism of immunogenic cell death induced by NIR-PIT[11]
    Fig. 2. Biological mechanism of immunogenic cell death induced by NIR-PIT[11]
    Binding site barrier of APC in tumor[22]
    Fig. 3. Binding site barrier of APC in tumor[22]
    Mechanism and related immunological effects of different target NIR-PIT[10]
    Fig. 4. Mechanism and related immunological effects of different target NIR-PIT[10]
    Target moleculeAPCCancerTumor modelRef.
    CD25Anti-CD25-IgG-IR700,Colon cancerIn vitro and in vivo32
    Anti-CD25-F(ab')2-IR700Colon cancer,lung carcinoma,and prostate cancerIn vitro and in vivo29
    CD73αCD73-IR700Pancreatic ductal adenocarcinoma subcutaneous and breast cancer(orthotopic)In vitro and in vivo35
    FAPAnti-FAP-IR700Esophageal squamous cell carcinomaIn vitro and in vivo44
    Anti-FAP-α-IR700Esophageal cancerIn vitro and in vivo43
    Integrin αvβ3cRGD-PEG-HSA-IR700Ovarian tumor spheroidIn vitro(3D culture)50
    IR700-PEG-PGlu-cRGDxGlioblastomaIn vitro(3D culture)51
    RGD-8PEG-IR700Melanoma spheroidIn vitro(3D culture)52
    PDGFRβDimeric Z-PDGFRβ-IR700Colorectal cancerIn vitro and in vivo49
    PodoplaninAnti PDPN-IR700Oral cancerIn vitro and in vivo53
    VEGFR-2DC101-IR700Gastric cancerIn vitro and in vivo48
    VISTAAnti-VISTA-IR700Colon cancer and lung carcinomaIn vitro and in vivo37
    Table 1. Therapeutic targets on non-tumor cells in TME
    Yingshu Cui, Yi Li, Xiaosong Li. Recent Advancements in Near‐Infrared Light Immunotherapy Targeted on Tumor Microenvironment[J]. Chinese Journal of Lasers, 2024, 51(9): 0907010
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