Within a diamond-anvil cell, the in-situ Raman spectroscopic study of silicone fluid was operated at room temperature 298.1 K and under pressures from 0.1 to 5 140.2 MPa. The present study analyzed the correlation of the modes 2 906 and 2 967 cm-1 with different pressures, indicating that their wavenumbers linearly increased with increasing pressure. Therefore, this provided the potential to consider the pressure medium silicone fluid as a pressure gauge. The result suggested that silicone fluid could be used as a reliable pressure gauge in high-pressure experiments using diamond-anvil cells with Raman spectrometer, and the correlations between pressure and (Δνp)2 906, (Δνp)2 967 are, p=-0.05［(Δνp)2 967］2+73.07(Δνp)2 967+91.54 and p=0.14［(Δνp)2 906］2+81.9(Δνp)2 906+92.01, respectively.