In fiber Brillouin sensing, the problem of ambiguous judgment caused by intrinsic cross between the temperature and the strain has always been a research hot topic in the field of distributed optical fiber sensing. In response to this problem, four types of solutions are introduced in detail, which are laying reference fiber, two-parameter matrix equation measurement, combination of two physical effects and special fiber discrimination. The principles, system, sensing performance and characteristics of each specific solution are analyzed, and these methods are discussed, compared and evaluated. Finally, it summarizes and looks forward to the research direction of solving cross-sensitivity issues.