Qujia Gold Deposit is located in the Zhaoyuan-Laizhou gold metallogenic belt in the Jiaodong area and is a new achievement in deep geological prospecting. Research samples are not easy to obtain, so portable XRF analyzer is used for analysis, Portable XRF analyzer has three features, it is small in size so easy to carry, the analysis speed is fast and does not need to destroy the sample, so the analysis result can be quickly obtained without losing the core sample. The study can be divided into the following three aspects, using the rock samples of Jidong area with similar lithology and accurate chemical analysis data to determine the test curve and establish a mathematical model, and then using the portable XRF analyzer to test the core samples of Qujia Gold Deposit, after calibration and replenishment, a batch of test data is obtained. Some samples are selected for pulverization treatment and tested by an X-ray fluorescence analyzer, and the test results of the portable XRF analyzer and the X-ray fluorescence analyzer are compared. Then using the data to analyze the geochemical characteristics of Qujia Gold Deposit, and the core element composition, element vertical distribution characteristics and element association of Qujia Gold Deposit were obtained. The results show that the portable XRF analyzer has accurate and reliable test results for rock samples, the test error is within the allowable range, the accuracy is less than that of the traditional analytical test technology, but it is completely problem-free to apply qualitative analysis and semi-quantitative analysis to the field. The portable XRF analyzer test data corrected and supplemented by the mathematical model fits well with the test data of the X-ray fluorescence analyzer, the factors affecting the accuracy of the portable XRF analyzer for testing the rock sample are mainly the uneven distribution of the rock sample component, the smaller the level, the more uniform the composition, the smaller the test error. When testing, where the composition is more uniform should be selected, or observe the rock samples before the test, assign the test points according to the proportion of the components, and try to take the average as many times as possible. Using the test data to carry out the geochemical study of Qujia Gold Deposit, the analysis results are in good agreement with the known geological conditions, and the reliability of the portable XRF analyzer test data is confirmed from another angle. The core samples have a higher content of Si and Al, and from the surrounding rock to the fracture zone. The K, Ca, S and other microelements and Cu, Pb, Zn and other indicator elements of gold are all enriched. The results of the study generally indicate that the portable XRF analyzer has a good application effect in Qujia Gold Deposit and can be promoted.