The aerospace electrical connectors with electronic glass as sealing material are widely used in aerospace field. Taking the air tightness of electronic glass sealed aerospace electrical connectors as optimization goal, the sealing process of electrical connectors was optimized. Taking the leakage rate of electrical connectors as response objective function, the Box-Behnken design and response surface analysis were used to evaluate the sealing process conditions. The quadratic polynomial regression equation model was established, and the regression equation was analyzed by variance and systematically test. The process parameters such as sealing temperature, sealing time and nitrogen flow were optimized. The results show that the optimal sealing process conditions are heating rate of 10 ℃/min, sealing temperature of 944 ℃, sealing time of 32 min, nitrogen flow rate of 1 408 L/h, and cooling rate of 10 ℃/min. The average leakage rate of aerospace electrical connectors under these conditions is 4.07×10-10 Pa·m3·s-1, which is consistent with the predicted value of regression model. The mechanism of glass and metal sealing is chemical bonding and physical meshing between glass and metal, and the good wetting between glass and metal oxide.