With the high speed progress of infrared detector technology, the Real-time processing of infrared signals meets a biggish challenge.When executing more complicated processing arithmetic, the Signal Process-ing Platform based on trad framework is hard to meet the demand of real-time processing in the infrared system with a detector which has more cells and higher frame speed.With the developing of General Processing Graphic Processing Unit(GPGPU), it provides the better platform for Real-time infrared signal processing.According to the characteristic of Real-time processing in the infrared system, a new type platform based on FPGA+CPU+GPU framework to process infrared signals was constructed and applied practically.The experiment results indi-cate that the platform is equal to the Real-time signal processing task of the infrared system in which the detector has more cells, higher frame speed, and more complicated arithmetic.