1School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 5872, China
2Hefei National Laboratory for Physical Sciences at the Microscale, Department of Physics, University of Science and Technology of China, Hefei 3006, China
Li Li, Kai-Yu Mak, Yan Zhou. Detection of HIV-1 antigen based on magnetic tunnel junction sensors[J]. Chinese Physics B, 2020, 29(8):
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We report a p24 (HIV disease biomarker) detection assay using an MgO-based magnetic tunnel junction (MTJ) sensor and 20-nm magnetic nanoparticles. The MTJ array sensor with sensing area of 890 × 890 μm2 possessing a sensitivity of 1.39 %/Oe was used to detect p24 antigens. It is demonstrated that the p24 antigens could be detected at a concentration of 0.01 μg/ml. The development of bio-detection systems based on magnetic tunnel junction sensors with high-sensitivity will greatly benefit the early diagnosis of HIV.