The noise figure is an very important factor which can limit the detection capability of the photoelectric detection circuit. To solve the problem, a photoelectric detection circuit was designed in the condition of the photodiode reverse bias, and then the circuit noise was analyzed indetail. When analyzing the noise, the structure of the photoelectric detection circuit was focused on. The whole circuit could be equivalent to three cascade module which were the photodiode module, the triode module and the operational amplifier module. Then, the noise source and the associated factors of each module were analyzed, and the output noise voltage of each module was calculated. Finally, the output noise voltage model of the whole circuit could be obtained. At last, the parameters of the whole circuit were determined according to the module, the circuit was built, the noise of circuit was measured, the accuracy of the output voltage model was verified. It realizes the design of photoelectric detection circuit.