Mid-infrared (mid-IR) (2 – 20 μm) photonics has numerous chemical and biologic “fingerprint” sensing applications due to characteristic vibrational transitions of molecules in the mid-IR spectral region. Unfortunately, compared to visible light and telecommunication band wavelengths, photonic devices and applications have been difficult to develop at mid-IR wavelengths because of the intrinsic limitation of conventional materials. Breaking a new ground in the mid-IR science and technology calls for revolutionary materials. Graphene, a single atom layer of carbon arranged in a honey-comb lattice, has various promising optical and electrical properties because of its linear dispersion band structure and zero band gap features. In this review article, we discuss recent research developments on mid-IR graphene photonics, in particular ultrafast lasers and photodetectors. Graphene-photonics-based biochemical applications, such as plasmonic sensing, photodynamic therapy, and florescence imaging are also reviewed.