• Laser & Optoelectronics Progress
  • Vol. 59, Issue 5, 0530004 (2022)
Wei Hou1, Jifen Wang1、*, Leiping Zhang2, Xinyu He1, and Yilin Xie2
Author Affiliations
  • 1School of Investigation, People's Public Security University of China, Beijing 100038, China
  • 2Institute of Forensic Science, Ministry of Public Security, Beijing 100038, China
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    DOI: 10.3788/LOP202259.0530004 Cite this Article Set citation alerts
    Wei Hou, Jifen Wang, Leiping Zhang, Xinyu He, Yilin Xie. Spectral Pattern Recognition of Sedative-Hypnotic Drugs in the Perspective of Drug Safety[J]. Laser & Optoelectronics Progress, 2022, 59(5): 0530004 Copy Citation Text show less
    Infrared spectra of three kinds of sedative-hypnotic drugs. (a) Clozapine; (b) promethazine; (c) phenobarbital
    Fig. 1. Infrared spectra of three kinds of sedative-hypnotic drugs. (a) Clozapine; (b) promethazine; (c) phenobarbital
    Classification accuracies of three kinds of sedative-hypnotic drugs under different regions of derivative spectra. (a) First derivative spectra; (b) second derivative spectra
    Fig. 2. Classification accuracies of three kinds of sedative-hypnotic drugs under different regions of derivative spectra. (a) First derivative spectra; (b) second derivative spectra
    Classification accuracy of intermediate fusing spectrum under RF model
    Fig. 3. Classification accuracy of intermediate fusing spectrum under RF model
    Two-dimensional distribution map of three kinds of sedative-hypnotic drugs
    Fig. 4. Two-dimensional distribution map of three kinds of sedative-hypnotic drugs
    Infrared spectra of four unknown samples. (a) M1; (b) M2; (c) M3; (d) M4
    Fig. 5. Infrared spectra of four unknown samples. (a) M1; (b) M2; (c) M3; (d) M4
    SpectraClassification accuracy /%
    Training setTest set
    DTRBFRFDTRBFRF
    Full81.2564.0675.0067.8560.7176.92
    Fingerprint82.8178.5779.6871.4271.4377.78
    Functional group68.7567.1971.8853.5764.2870.37
    Table 1. Classification accuracies of three kinds of sedative-hypnotic drugs under different regions of original spectra
    ItemClassification accuracy
    Average fusionDifference fusionTandem fusion
    DTQ165.2265.2293.48
    Q265.2265.2289.13
    Q365.2265.2293.48
    RBFQ165.2265.2265.22
    Q265.2265.2265.22
    Q365.2265.2278.26
    RFQ186.9686.9695.65
    Q286.9686.9689.13
    Q384.7884.7893.48
    Table 2. Classification accuracy of three kinds of sedative-hypnotic drugs under different types of fusion
    SampleBenzodiazepineBarbituratePhenothiazine
    M1
    M2
    M3
    M4
    Table 3. Classification results of four unknown samples
    Wei Hou, Jifen Wang, Leiping Zhang, Xinyu He, Yilin Xie. Spectral Pattern Recognition of Sedative-Hypnotic Drugs in the Perspective of Drug Safety[J]. Laser & Optoelectronics Progress, 2022, 59(5): 0530004
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