The human bone appears as a hierarchical structure composed of cortical bone with high density and strength and cancellous bone with low density and blood vessels. Therefore, the structure and mechanical properties of human implants should match the characteristics of human bone. Based on the stress on the natural human bone, the titanium alloy porous structure designed by topology optimization method was fabricated by laser powder bed fusion (LBPF). The mechanical properties and deformation failure mode of the porous structure were analyzed by compression experiment and numerical simulation. It was found that the numerical simulation and experimental results have a high consistency in the current work. Finally, by comparing with the mechanical properties of human natural bone, combined with the failure mode of porous structure, a porous material suitable for human implants was obtained.