Contents
2022
Volume: 15 Issue 6
9 Article(s)

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Research Articles
Special issue on enhanced photodynamic therapy: Part II
Buhong Li, and Lothar Lilge
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 15, Issue 6, 2202003 (2022)
Cerium-based nanoparticles for cancer photodynamic therapy
Hui Li, Min Wei, Xinyi Lv, Yanling Hu, Jinjun Shao, Xuejiao Song, Dongliang Yang, Wenjun Wang, Buhong Li, and Xiaochen Dong
Metal- and metal-oxide-based nanoparticles have been widely exploited in cancer photodynamic therapy (PDT). Among these materials, cerium-based nanoparticles have drawn extensive attention due to their superior biosafety and distinctive physicochemical properties, especially the reversible transition between the valenc
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 15, Issue 6, 2230009 (2022)
Photoswitchable semiconducting polymer dots with photosensitizer molecule and photochromic molecule loading for photodynamic cancer therapy
Lu Guo, Bo Xu, Haobin Chen, and Ying Tang
Photodynamic therapy (PDT) is a new and rapidly developing treatment modality for clinical cancer therapy. Semiconductor polymer dots (Pdots) doped with photosensitizers have been successfully applied to PDT, and have made progress in the field of tumor therapy. However, the problems of severe photosensitivity and limi
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 15, Issue 6, 2240007 (2022)
Three-dimensional quantification of protoporphyrin IX in photodynamic therapy using SFDI/DFT: A pilot experimental validation
Mai Dan, Weijie Song, Meihui Liu, Yaru Zhang, and Feng Gao
Photodynamic therapy (PDT) dosimetry, including light dose, photosensitizer dose and tissue oxygen, has been a research focus in PDT. In this work, we present a three-dimensional (3D) quantification of protoporphyrin IX (PpIX) using combined spatial frequency domain imaging (SFDI) and diffuse fluorescence tomography (D
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 15, Issue 6, 2240008 (2022)
A novel BODIPY-based nano-photosensitizer with aggregation-induced emission for cancer photodynamic therapy
Yuting Zhang, Guojing Li, Jiong Li, Ming Wu, Xiaolong Liu, and Jingfeng Liu
The discovery of aggregation-induced emission (AIE) effect provides opportunities for the rapid development of fluorescence imaging-guided photodynamic therapy (PDT). In this work, a boron dipyrromethene (BODIPY)-based photosensitizer (ET-BDP-O) with AIE characteristics was developed, in which the two linear arms of BO
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 15, Issue 6, 2240009 (2022)
Photoinactivation of Escherichia coli using five photosensitizers and the same number of photons
Daniel Ortega-Zambrano, Denisse Fuentes-López, and Hilda Mercado-Uribe
Bacterial resistance is today a matter of great medical concern, so it is urgent to investigate alternatives to alleviate it. Photodynamic inactivation (PDI) is a method that has been endorsed to inactivate different pathogens, including bacteria, fungi and viruses. PDI is achieved by using a photosensitizer (PS) molec
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 15, Issue 6, 2240010 (2022)
Monitoring of time-resolved singlet oxygen luminescence at 1270nm by an optical fiber detection system
Cheng Zhang, Hongxin Lin, Ying Hu, Jian Sui, Lisheng Lin, and Buhong Li
Singlet oxygen (1O2) is the main cytotoxic substance in Type II photodynamic therapy (PDT). The luminescence of 1O2 at 1270nm is extremely weak with a low quantum yield, making the direct detection of 1O2 at 1270nm very challenging. In this study, a set of highly sensitive optical fiber detection system is built up to
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 15, Issue 6, 2240011 (2022)
A portable illumination device for photodynamic therapy of the oral cavity
Jiyuan Xiong, Xu Wang, Xiaoming Hu, Ying Han, and Qin Li
Photodynamic therapy (PDT) is a minimally invasive method for treating oral leukoplakia. In this paper, we propose a portable PDT device consisting of a flexible circuit board with a liquid flow cooling module on the back. The light source size was 17mm×11mm×4mm, and the irradiation area of the light source w
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 15, Issue 6, 2240012 (2022)
Ultrasmall pH-responsive silicon phthalocyanine micelle for selective photodynamic therapy against tumor
Yiming Zhou, Wenlong Zeng, Mengxuan Wang, Rui Li, Xiuli Yue, and Zhifei Dai
Targeted photodynamic therapy (TPDT) based on the photosensitizers responsive for tumor microenvironment is promising because of the better anti-tumor effect and less phototoxicity against normal tissue than the traditional PDT. Nanoparticle-based stimuli-responsive photosensitizers have been widely explored for TPDT.
Journal of Innovative Optical Health Sciences
  • Publication Date: Jan. 01, 1900
  • Vol. 15, Issue 6, 2250035 (2022)