Vector vortex beams (VVBs) have attracted significant attention in both classical and quantum optics. Liquid crystal (LC), beyond its applications in the information display, has emerged as a versatile tool for manipulating VVBs. In this review, we focus on the functions and applications of typical LC devices in recent studies on controlling the space-variant polarized vortex light. Manipulation of VVBs through patterned nematic LC optical elements, patterned cholesteric LC optical elements, self-assembled defects, and LC spatial light modulators are discussed separately. Moreover, LC-based novel optical applications in the field of quantum information are reviewed.